Abstract: Based on the estimated vegetation coverage (VC) in Liaoning province using MODIS-NDVI data and mixed pixel decomposition model, the spatio-temporal evolution of VC and its responses to climatic factors were investigated.The results show that the VC experiences a fluctuating increasing trend with an average annual rate of 0.38% from 2000 to 2018.The region with increasing trend accounts for 92.3% of the vegetated area.The bare land and low-coverage area decrease year by year, and the percentages of the middle-low, middle and high coverage areas increase by 11.35%, 11.00% and 9.22%, respectively, since 2000.The relationships between the VC and climatic factors show significant spatial variability.Specifically, the VC in the west of Liaoning which is drought prone region is negatively correlated with temperature and positively correlated with precipitation.However, the VC in the east of Liaoning has positive and negative relationships with temperature and precipitation, respectively.Besides, the VC has a lag response of one month to the precipitation, but not to the temperature in Liaoning province.